ABSTRACT
Objective: In this study, we aimed to analyze real-time reverse transcription-polymerase chain reaction (RT-PCR) positive elderly patients (>= 65 years old) admitted to the hospital with symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection regarding their vaccination status.Methods: The study included 151 COVID-19 patients aged >= 65 years old, admitted to the hospital between March 10 and June 30, 2021. The study group was divided into two groups: Group 1 consisted of patients who had two doses of inactive vaccine, administered at four weeks interval, and Group 2 consisted of unvaccinated patients who had no vac-cination at all or got one dose of vaccine or had an infection within 15 days of completion of the vaccination schedule. We compared the two groups based on demographic, clinical, laboratory, and mortality data.Results: Groups 1 and 2 included 78 and 73 patients, respectively. There was no significant difference between groups regarding gender distribution, age, intensive care admission, number of underlying diseases, and laboratory and radio-logical findings. However, the number of comorbidities and mortality showed a significant positive correlation. Also, the presence of desaturation was significantly associated with mortality.Conclusion: In this study, we established that an inactive virus vaccine had no significant protectivity for the severity of disease and mortality in the elderly population.
ABSTRACT
BACKGROUND AND AIM: This study aimed to investigate the association of the chest computed tomography severity score (CT-SS) with mortality in patients who were admitted to the intensive care unit (ICU) with coronavirus disease 2019 (COVID-19) pneumonia. METHODS: In this single-center retrospective observational study, we reviewed the radiological and medical records of 45 patients with confirmed COVID-19, requiring ICU admission during a 4 month period. The chest CT-SS was used to evaluate the severity of lung involvement. RESULTS: Forty-five patients who admitted to the ICU with COVID-19 and had undergone chest CT scans on admission were enrolled. There wasn't a significant difference in total CT-SS neither between patients who died and those who survived [median (interquartile range) 22 (11-30) vs 16 (9-18), p=0.20] nor between patients who underwent invasive mechanical ventilation and those who did not [median (interquartile range) 22 (12-30) vs 15 (8-17), p=0.17]. The median of CT-SS was 17 (2-39) (n=23 vs n=22). The area under the curve for estimation of mortality according to CT-SS was 0.611 at a 95% CI of 0.434-0.788 (p=0.20). CONCLUSIONS: The total CT-SS, obtained from the chest CT on admission to the ICU, was not associated with an increased risk of mortality in patients admitted to ICU with COVID-19 pneumonia.
ABSTRACT
Objective: In this study, we aimed to analyze real-time reverse transcription-polymerase chain reaction (RT-PCR) positive elderly patients (≥ 65 years old) admitted to the hospital with symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection regarding their vaccination status. Methods: The study included 151 COVID-19 patients aged ≥ 65 years old, admitted to the hospital between March 10 and June 30, 2021. The study group was divided into two groups: Group 1 consisted of patients who had two doses of inactive vaccine, administered at four weeks interval, and Group 2 consisted of unvaccinated patients who had no vaccination at all or got one dose of vaccine or had an infection within 15 days of completion of the vaccination schedule. We compared the two groups based on demographic, clinical, laboratory, and mortality data. Results: Groups 1 and 2 included 78 and 73 patients, respectively. There was no significant difference between groups regarding gender distribution, age, intensive care admission, number of underlying diseases, and laboratory and radiological findings. However, the number of comorbidities and mortality showed a significant positive correlation. Also, the presence of desaturation was significantly associated with mortality. Conclusion: In this study, we established that an inactive virus vaccine had no significant protectivity for the severity of disease and mortality in the elderly population.
ABSTRACT
BACKGROUND: The aim of this study was to determine mortality rates and to evaluate clinical features of coronavirus disease 2019 (COVID-19) patients with septic shock in intensive care unit (ICU). MATERIALS AND METHODS: The medical records of COVID-19 patients requiring ICU admission were retrospectively reviewed over a 3-month period. RESULTS: Forty patients with COVID-19 admitted to the ICU were screened. Two patients died within 24 h after ICU admission. After these patients were excluded, septic shock was detected in 11 (28%) of 38 patients during the 30-day follow-up period. Ten (91%) of the 11 patients with septic shock died in the ICU. Eight (72%) of the 11 patients had nosocomial infection during 30-day follow-up period. Six (54%) of 11 septic shock patients had positive culture results for bacterial pneumonia on the day of septic shock. The median time from symptom onset to septic shock was 14 (5-34) days. The median duration from ICU admission until septic shock was 8 (1-28) days. All of the patients with septic shock underwent invasive mechanical ventilation (IMV). CONCLUSION: COVID-19 patients with septic shock have higher mortality rates, percentage of nosocomial infection, and IMV requirement.
ABSTRACT
Introduction: A pandemic emerged in 2020 in Wuhan, China because of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus infection. It rapidly disseminated all over the world in a short time. This study described the demographic and clinical features of 479 coronavirus disease-2019 patients admitted to a designated pandemic hospital in Izmir, Turkey, and it aimed to incorporate our experiences into current literature. Materials and Methods: Patients confirmed with symptomatic SARS-CoV-2 infection by real-time polymerase chain reaction or by typical chest computed tomography findings and rapid antibody test positivity were enrolled in the study. Demographic and clinical data of the patients were extracted from electronic medical recordings. The patients were categorized into three groups based on the severity of clinical and laboratory findings: group 1, uncomplicated disease;group 2, mild/moderate disease;and group 3, severe disease. Demographic and clinical findings were compared between groups. Results: The mean age of the patients was 50.7 +/- 19.3 years;50.5% of the patients were male. No significant difference was observed between gender distributions in groups. The most common symptoms on admission were cough (219, 45.7%), fever (187, 39%), fatigue (176, 36.7%), and dyspnea (63, 13.2%). The most frequently observed comorbidities were hypertension (129, 26.9%), diabetes (71, 14.8%), and chronic heart diseases (35, 7.3%). The patients in group 3 had shown significantly higer number of underlying diseases. On chest computed tomography, ground-glass opacity was the most common radiologic finding. C-reactive protein, D-dimer, ferritin, and procalcitonin were found to be in significantly increased levels in patients with severe disease. Conclusion: Our observations during the first three months of pandemic suggested that the patients can present with a varying degree of severity. Some prognostic markers can predict the progression of the disease. We emphasize that accumulating experiences in the management of the disease accompanied by up-to-date tracking of guidelines would enable us to face up against upcoming surges more effectively.